Universal pipeline for high-resolution GPCR structure determination.
Europe PMC REST API · Indexed academic record · Source published: Fri Aug 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time) · Indexed here: Thu Oct 08 2026 09:07:53 GMT+0000 (Coordinated Universal Time)
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G protein-coupled receptors (GPCRs) regulate human physiology and are major drug targets. Although cryo-electron microscopy has accelerated GPCR structural biology, inactive-state structures remain difficult because current fusion-based strategies often require extensive experimental screening to identify rigid constructs suitable for high-resolution reconstruction. Here we introduce a universal p
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