Engineering human multi-organ tissue chip niches for drug absorption, distribution, metabolism, excretion and toxicity prediction.
PubMed / NCBI E-utilities · Indexed academic record · Source published: Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time) · Indexed here: Thu Oct 08 2026 09:09:29 GMT+0000 (Coordinated Universal Time)
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Predicting human drug responses in vitro remains a central challenge in drug development. Animal models have shown limited accuracy in recapitulating human drug absorption, distribution, metabolism, excretion and toxicity, which arise from coordinated activities across multiple organs. Multi-organ-on-a-chip systems (mOoCs) are a class of promising new approach methodologies that can reconstruct th
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