Sparks of function by de novo protein design.
Europe PMC REST API · 學術索引收錄 · 來源發佈：Thu Feb 15 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · 本站收錄：Thu Oct 08 2026 09:08:13 GMT+0000 (Coordinated Universal Time)
已保存的原文節選
Information in proteins flows from sequence to structure to function, with each step causally driven by the preceding one. Protein design is founded on inverting this process: specify a desired function, design a structure executing this function, and find a sequence that folds into this structure. This 'central dogma' underlies nearly all de novo protein-design efforts. Our ability to accomplish
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