Sparks of function by de novo protein design.
Europe PMC REST API · Indexed academic record · Source published: Thu Feb 15 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · Indexed here: Thu Oct 08 2026 09:08:13 GMT+0000 (Coordinated Universal Time)
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Information in proteins flows from sequence to structure to function, with each step causally driven by the preceding one. Protein design is founded on inverting this process: specify a desired function, design a structure executing this function, and find a sequence that folds into this structure. This 'central dogma' underlies nearly all de novo protein-design efforts. Our ability to accomplish
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