Multistate and functional protein design using RoseTTAFold sequence space diffusion
Crossref REST API · 學術索引收錄 · 來源發佈：Wed Sep 25 2024 00:00:00 GMT+0000 (Coordinated Universal Time) · 本站收錄：Thu Oct 08 2026 09:21:33 GMT+0000 (Coordinated Universal Time)
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Abstract Protein denoising diffusion probabilistic models are used for the de novo generation of protein backbones but are limited in their ability to guide generation of proteins with sequence-specific attributes and functional properties. To overcome this limitation, we developed ProteinGenerator (PG), a sequence space diffusion model based on RoseTTAFold that simultaneously generates protein se
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