Atomically accurate de novo design of antibodies with RFdiffusion
Crossref REST API · Indexed academic record · Source published: Wed Nov 05 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Indexed here: Thu Oct 08 2026 09:15:50 GMT+0000 (Coordinated Universal Time)
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Abstract Despite the central role of antibodies in modern medicine, no method currently exists to design novel, epitope-specific antibodies entirely in silico. Instead, antibody discovery currently relies on immunization, random library screening or the isolation of antibodies directly from patients 1 . Here we demonstrate that combining computational protein design using a fine-tuned RFdiffusion
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