Structure and evolution-guided design of minimal RNA-guided nucleases.
Europe PMC REST API · 學術索引收錄 · 來源發佈：Thu Jul 16 2026 00:00:00 GMT+0000 (Coordinated Universal Time) · 本站收錄：Thu Oct 08 2026 09:07:53 GMT+0000 (Coordinated Universal Time)
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The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic properties remains challenging. Here, we use a protein design strategy that couples a structure-guided inverse-folding model with evolution-informed residue constraints to generate active, divergent v
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