Miniaturizing and modifying natural proteins with Raygun.
Europe PMC REST API · Indexed academic record · Source published: Wed Jul 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time) · Indexed here: Thu Oct 08 2026 09:08:13 GMT+0000 (Coordinated Universal Time)
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Proteins have evolved over billions of years through coordinated substitutions, insertions and deletions, yet computational protein design cannot fully replicate nature's ability to engineer new proteins from existing templates. Protein language models 1-3 generate informative per-residue representations, but harnessing them for large-scale, function-preserving sequence modifications has remained
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