Sequence and structural determinants of efficacious de novo chimaeric antigen receptors.
PubMed / NCBI E-utilities · Indexed academic record · Source published: Wed Sep 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time) · Indexed here: Thu Oct 08 2026 09:08:08 GMT+0000 (Coordinated Universal Time)
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Advances in generative protein design using artificial intelligence (AI) have enabled the rapid development of binders against heterogeneous targets, including tumour-associated antigens. Despite extensive biochemical characterization, these novel protein binders have had limited evaluation in candidate therapeutics, including chimaeric antigen receptor (CAR) T cells. Here we synthesize generative
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